Just Published!

We have just published a tutorial review article “Molecular methods for assessment of non-covalent metallodrug–DNA interactions” in the RSC journal Chemical Society Reviews!

This article covers a number of key learning points including:

• Essentials of nucleic acid structure.

• Principles of nucleic acid–metallodrug recognition.

• Application of mass spectrometry, nuclear magnetic resonance spectroscopy and X-ray crystallography to probe selective metallodrug–DNA binding sites.

• Quantification of metallodrug–DNA interactions using high-throughput optical techniques based on fluorescence and absorbance spectroscopy.

• Electrophoretic techniques and the use of on-chip microfluidic assays to identify drug–DNA damage.

Check it out here.