Papers

2018

41. Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands
P.de Souza I., de P.Machado B., B.de Carvalho A., Binatti I., Krambrock K., Molphy Z., Kellett A., C.Pereira-Maia E., P. Silva-Caldeira P. Journal of Molecular Structure, 1178; 18-28, 2019.

40. [Cu(TPMA)(Phen)]: metallo-drug nanocontainer delivery and membrane lipidomics of a neuroblastoma cell line coupled with a liposome biomimetic model focusing on fatty acid reactivity
Toniolo, G., Louka, M., Menounou, G., Fantoni, N.; Mitrikas, G.; Efthimiadou, E., Masi, A., Bortolotti, M., Polito, L., Bolognesi, A., Kellett, A., Ferreri, C., Chatgilialoglu, C. ACS Omega, accepted, 2018. 

39. Recent advances in anticancer copper compounds
Kellett A., Molphy Z., Slator C., McKee V. RSC Metallobiology Series, accepted, 2018. 

38. Polypyridyl-based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease
Zuin Fantoni N., Molphy Z., Slator C., Menounou G., Toniolo, G., Mitrikas G., McKee V., Chatgilialoglu C., Kellett A. Chem. Eur. J., accepted, 2018.

37. A Phosphate-Targeted Dinuclear Cu(II) Complex Combining Major Groove Binding and Oxidative DNA Cleavage
Molphy Z., Montagner D., Bhat S., Slator C., Long C., Erxleben A., Kellett A. Nucleic Acids Res., accepted, 2018. 

36. An Innovative DNA-Targeted Metallo-Prodrug Strategy combining Histone Deacetylase Inhibition with Oxidative Stress
McGivern T., Slator C., Kellett A., Marmion C. Molecular Pharmaceutics, accepted, 2018. 

35. In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes
Rochford G., Molphy Z., Browne N., Surlis C., Devereux M., McCann M., Kellett A., Howe O., Kavanagh K. J. Inorg. Biochem., 186: 135-146, 2018. 

34. Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination
Slator C., Molphy Z., Long C., McKee V., Brown T., Kellett A. Nucleic Acids Res., 46 (6): 2733-2750, 2018. 


2017

33. Opioid architectures as new DNA binding molecules
McStay N., Molphy Z., Gathergood N., Kellett A. Symmetry, 28 (2): 195-161, 2017.

32. Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Slator C., Molphy Z., McKee V., Kellett A. Redox Biol., 12: 150-161, 2017.

31. C3-Symmetric Opioid Scaffolds are pH-Responsive DNA Condensation Agents
McStay N., Molphy Z., Coughlan A., Cafolla, A., McKee, V., Gathergood, N., Kellett, A. Nucleic Acids Res.45 (2): 527-540, 2017. 


2016

30. Radical-induced purine lesion formation is dependent on DNA helical topology
Terzidis M.A., Prisecaru A., Molphy Z., Barron N., Randazzo A., Dumont E., Krokidis M.G., Kellett A., Chatgilialoglu C. Free Rad. Res., 50: S91-S101, 2016.

29. Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics 
Kelly P.S., McSweeney S., Clynes M., Meleady P., Barron N., Coleman O., Henry M., Carillo S., Bones J., Chandron D., Kellett A. Biotechnol. Progress32: 1547–1558, 2016.

28. Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity
Thornton L., Dixit V., Assad L., Ribeiro T., Queiroz D., Kellett A., Casey A., Colleran J., Pereira M., Rochford G., McCann M., O'Shea D., Dempsey R., McClean S., Kia A., Walsh M., Creaven B., Howe O., Devereux M. J. Inorg. Biochem., 159: 120-132, 2016.

27. [Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction
Slator C., Barron N., Howe O., Kellett A. ACS Chem. Biol.11 (1): 159–171, 2016.

26. Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells
Viganor, L., Galdino, A.C., Nunes, A.P., Santos, K., Branquinha M., Devereux, M., Kellett, A., McCann, M., Santos, A. J.  J. Antimicrob. Chemother.,71 (1): 128-134, 2016.


2015

25. Genome Engineering with Synthetic Copper Nucleases
Fantoni N., Lauria T., Kellett A.  Synlett., 26 (19), 2623-2626, 2015. 
[Invited Manuscript - Synpact]

24. Protein engineering with artificial chemical nucleases
Larragy R., Fitzgerald J., Prisecaru A., McKee V., Leonard P. and Kellett A. Chem. Commun., 51, 12908-12911, 2015.
[Front Cover]

23. DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases
Molphy Z., Slator C., Chatgilialoglu C., Kellett A. Front. Chem., 3 (18), 1-9, 2015.


2014

22. The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes
Prisecaru A., Molphy Z., Kipping R.G., Peterson E.J., Qu Y., Kellett A., and Farrell N.P. Nucleic Acids Res., 42 (22), 13474-13487, 2014.

21. Copper Phenanthrene Oxidative Chemical Nucleases
Molphy Z., Prisecaru A., Slator C., Barron, N., McCann M., Colleran J., Chandran D., Gathergood N., Kellett A., Inorg. Chem., 53 (10), 5392-5404, 2014.


2013

20. Synthesis, Structure and Biological Activity of Silver(I) Complexes of Substituted Imidazoles
McCann M., Curran R., Ben-Shoshana M., McKee V., Devereux M., Kavanagh K., Kellett A. Polyhedron, 56, 180-188, 2013.

19. Regulating Bioactivity of Cu2+ Bis-1,10-Phenanthroline Artificial Metallonucleases with Sterically Functionalised Pendant Carboxylates
Prisecaru A., Mckee V., Howe O., Rochford G., McCann M, Colleran J., Barron N., Pour M., Gathergood N. and Kellett A. J. Med. Chem., 56 (21), 8599-8615, 2013.

18. A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction
McCann M., McGinley J., Ni K., O'Connor M., Kavanagh K., McKee V., Colleran J., Devereux M., Gathergood N., Barron N., Prisecaru A. and Kellett A. Chem. Commun., 49, 2341-2343, 2013.

17. Metal-Based Antimicrobial Protease Inhibitors
Kellett A., Prisecaru A., Slator C., Molphy Z., McCann M. Curr. Med. Chem.20 (25), 3134-3151, 2013.


2012

16. Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities exhibit low toxicity and display promising chemotherapeutic potential with fast acting in-vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines
O'Connor M., Kellett A., McCann M., Rosair G., McNamara M., Howe O., Creaven B., McClean S., Foltyn-Arfa Kia A., O'Shea D., Devereux M. J. Med. Chem., 55 (5), 1957-1968, 2012.

15. DNA Cleavage Reactions of the Dinuclear Chemotherapeutic Agent Copper(II) Bis-1,10-Phenanthroline Terephthalate
Kellett A., McCann M., Howe O., O'Connor M., Devereux M. Int. J. Clin. Pharmacol. Ther., 50 (1), 79-81, 2012.

14. Radical Induced DNA Damage by Cytotoxic Square-Planar Copper(II) Complexes Incorporating o-Phthalate and 1,10-Phenanthroline or 2,2'-Dipyridyl
Kellett A., Howe O., O'Connor M., McCann M., Creaven B., McClean S., Foltyn-Arfa Kia A., Casey A., Devereux M. Free Rad. Biol. Med., 53 (3), 564-576, 2012.

13. Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(terephthalate)(1,10-phen)4]2+
Prisecaru A., Devereux M., Barron N., McCann M., Colleran J., Casey A., McKee V., Kellett A. Chem. Commun., 48 (55), 6906-6908, 2012.

12. Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity
McCann M., Curran R., Ben-Shoshan M., McKee V., Tahir A., Devereux M., Kavanagh K., Creaven B.,  Kellett A. Dalton Trans., 41 (21), 6516-6527, 2012.

11. In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes
McCann M., Santos A., da Silva B., Romanos M., Pyrrho A., Devereux M., Kavanagh K., Fichtner I., Kellett A. Tox. Res., 1 (1), 47-54, 2012.
[Cover Article]
[Editorial Highlight]

10. Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis
Santos A.L.S., Sodre C.L., Valle R.S., Silva B.A., Abi-chacra E.A., Silva L.V., Souza-Goncalves A.L., Sangenito L.S., Goncalves D.S., Souza L.O.P., Palmeira V.F., d'Avila-Levy C.M., Kneipp L.F., Kellett A., McCann M., Branquinha M.H. Curr. Med. Chem., 19 (17), 2715-2737, 2012.

9. Deciphering the Antimicrobial Activity of Phenanthroline Chelators
McCann M., Kellett A., Kavanagh K., Devereux M., Santos A.L.S. Curr. Med. Chem., 19 (17), 2703-2714, 2012.


2011

8. Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
Kellett A., O'Connor M., McCann M., Howe O., Casey A., McCarron P., McNamara M., Kennedy S., May D.D., Skell P.S., O'Shea D., Devereux M. Med. Chem. Comm., 2 (7), 569-676, 2011.
[Cover Article]
[Editorial Highlight]

7. Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties
Kellett A., O'Connor M., McCann M., McNamara M., Lynch P., Rosair G., McKee V., Creaven B., Walsh M., McClean S., Foltyn A., O'Shea D., Howe O., Devereux M. Dalton Trans., 40 (5), 1024-1027, 2011.


2010

6.  Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate) 
Kellett, A., Rosair G., Devereux M., McNamara M., McCann M. Acta Cryst. C., 66, M358-M362, 2010.

5. Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands
Creaven B. S., Czegledi E., Devereux M., Enyedy E. A., Foltyn-Arfa Kia A., Karcz D., Kellett A., McClean S., Nagy N. V., Noble A., Rockenbauer A.,Szabo-Planka T., Walsh M. Dalton Trans., 39 (45), 10854-10865, 2010.


2009

4. Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity
Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M.  J. Inorg. Biochem., 103, 9, 1196-1203, 2009.