Rebecca Lynn

Background: M.Sci. in Chemistry and Biology within the Natural Sciences Programme, 2022, Durham University

Research project title: Gene Editing with Nucleic Acid Click Chemistry (ENACT)

Project details: The primary aim is to develop a breakthrough class of artificial gene editing system for the treatment of human cancer. The technology is based on conjugating a therapeutic nucleic acid (TherON) probe to a copper complex that triggers targeted damage at the DNA interface. Using a multidisciplinary approach, the project will extend the boundaries of TherONs beyond existing classes and to pioneer the next-generation sequence-specific hybrid biomaterials through smart design that will eventually rival existing enzymatic-based state-of-art technologies. The goal is to target the unique base-base sequences present in genetic elements of recalcitrant cancers. The proposed TherONs will detect, bind, and eliminate genes unique to specific cancers for which there are no cures. Using 'click chemistry' technology, each TherON will carry an artificial metallonuclease (AMN) unit programmed to direct cutting a specific genetic locus that leads to targeted tumour destruction.

Funding: Irish Research Council (IRC)