Opioid Architectures as New DNA Binding Molecules
McStay N, Molphy Z., Gathergood N. Kellett A.
Symmetry: Culture and Science, 28 (2), 195-198, 2017.
Abstract: Herein we report the discovery of C3 symmetric opioid architectures as efficient DNA binding molecules. To our knowledge these agents are the first opioidbased structures with nucleic acid recognition properties. These architectures may now pave the way toward the development of a new class of semi-synthetic DNA binding molecule with potential applications in gene delivery