Nicolò Fantoni

Background:  BSc. Chemical Sciences and MSc. (Hons) Chemical Sciences –Università degli Studi di Padova, Italy.

Research project: Molecular scissors: synthetic DNA cutters.

The discovery of the first synthetic chemical nuclease [Cu(Phen)2] (where Phen = 1,10-phenanthroline) sparked intensive effort toward the development of new artificial metallonucleases with DNA cleavage mediated through reactive oxygen species (ROS) production. The active complex, however, exhibits numerous limitations including a high dissociation constant for the second coordinated phenanthroline ligand and a reliance on exogenous reductant to generate the active Cu+ species. With this in mind, this project focuses on the development of new DNA oxidants rationally designed to achieve increased stability in combination with the introduction of designer phenazine ligands can pronounce DNA recognition and intercalation.

Funding: ClickGene - Marie Sklodowska-Curie Innovative Training Network (ITN) ClickGene (H2020-MSCA-ITN-2014-642023).

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