Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M.  

Journal of Inorganic Biochemistry, 103, 9, 1196-1203, 2009.

Abstract: The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.