In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes

Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe and Kevin Kavanagh.

Journal of Inorganic Biochemistry, 186, 135-146, 2018.

In this article published in the Journal of Inorganic Biochemistry, we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of Cu-Phen, Cu-DPQ-Phen and Cu-DPPZ-Phen (where phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-ƒ:2′,3′-h]quinoxaline and DPPZ = dipyrido[3,2-a:2′,3′-c]phenazine). Our aim was to investigate the influence of the systematic extension of the ligated phenazine ligand in the Gmellonella model as a first step towards assessing the in-vivo tolerance and mode of action of the complex series with respect to the well-studied oxidative chemical nuclease, Cu-Phen.

[Open Access]