ChemPlusChem 2019

We have have just published an article in the Wiley journal ChemPlusChem reporting a codeine C3-opioid DNA condensing scaffold (CC3) rationally designed through informatics-based conformation generation and ab initio geometry optimisation. The scaffold undergoes protonation at physiological pH that allows for controlled compaction and release of nucleic acids.


Financial support for this work was provided by Marie Skłodowska-Curie Innovative Training Network (ITN) ClickGene [H2020-MSCA-ITN-2014-642023]; Science Foundation Ireland (15/CDA/3648) ; and the Synthesis and Solid-State Pharmaceutical Centre (SSPC).